NAPLEX National exam

Try 10 realistic pharmacy practice questions aligned with the NAPLEX National exam.

Answer each question, then click “Check my score” at the bottom of the page. You’ll see your total score plus the correct answers for every item.

How this free practice exam works

This 10-question mini-exam is designed to mirror the style and cognitive level of the NAPLEX National exam, with a focus on pharmacotherapy, calculations, pharmacokinetics, patient counseling, and professional pharmacy practice.

Choose one answer for each multiple-choice question.
Click “Check my score” to see how you did.
Instant feedback shows which questions are correct or incorrect and reveals the right answers.

This practice content is for preparation only and is not endorsed or approved by NABP, any state board of pharmacy, or testing provider. Always use the most current NAPLEX test plan and your state’s pharmacy laws and guidance.

NAPLEX National exam (10 Questions)

Question 1

A prescription is written for amlodipine 7.5 mg by mouth once daily. The pharmacy stocks 5 mg tablets. How many tablets should the patient take per dose?

A. 0.5 tablet B. 1 tablet C. 1.5 tablets D. 2 tablets

Question 2

A 65-year-old male (weight 80 kg, serum creatinine 1.2 mg/dL) is being evaluated for renal dosing. Using the Cockcroft–Gault equation, what is the best estimate of his creatinine clearance? (Assume ideal and actual body weight are the same.)

A. 25 mL/min B. 45 mL/min C. 70 mL/min D. 110 mL/min

Question 3

A drug has a half-life of 8 hours. If a patient’s plasma concentration is 40 mg/L immediately after a dose, approximately how long will it take for the concentration to fall to 5 mg/L, assuming first-order elimination?

A. 8 hours B. 16 hours C. 20 hours D. 24 hours

Question 4

A patient stabilized on warfarin for atrial fibrillation is started on a new antibiotic. Which medication is most likely to significantly increase the patient’s INR and bleeding risk through CYP2C9 inhibition?

A. Azithromycin B. Sulfamethoxazole/trimethoprim C. Ceftriaxone D. Amoxicillin

Question 5

A 58-year-old patient with type 2 diabetes and chronic kidney disease has an estimated GFR of 25 mL/min/1.73 m². The patient is currently taking metformin 1,000 mg twice daily. What is the most appropriate pharmacist recommendation regarding metformin therapy?

A. Discontinue metformin due to increased risk of lactic acidosis at this level of kidney function B. Continue the same dose because metformin is safe at all levels of kidney function C. Increase metformin to 1,500 mg twice daily to improve glycemic control D. Switch metformin to glyburide because it is preferred in kidney disease

Question 6

A 24-year-old patient with persistent asthma uses a short-acting beta-agonist inhaler three times per week and has nighttime symptoms twice per month. The only current therapy is the rescue inhaler as needed. According to standard treatment guidelines, which change is most appropriate?

A. Add a leukotriene receptor antagonist only B. Add a long-acting beta-agonist inhaler as monotherapy C. Initiate a low-dose inhaled corticosteroid in addition to the rescue inhaler D. Switch the rescue inhaler to an oral short-acting beta-agonist

Question 7

A 67-year-old patient with chronic obstructive pulmonary disease presents in October for refills. Which immunizations should the pharmacist most strongly recommend today, assuming the patient’s records show no contraindications and routine adult vaccines are due?

A. Live attenuated influenza vaccine only B. Tetanus and diphtheria toxoid only C. Human papillomavirus series and meningococcal conjugate vaccine D. Age-appropriate inactivated influenza vaccine and pneumococcal vaccination per current guidelines

Question 8

A patient is being treated with intravenous vancomycin for methicillin-resistant Staphylococcus aureus pneumonia. Which trough concentration range is generally recommended for serious infections such as pneumonia when using traditional trough-based monitoring?

A. 5–10 mcg/mL B. 15–20 mcg/mL C. 25–30 mcg/mL D. 30–40 mcg/mL

Question 9

A patient newly started on lisinopril reports a persistent, dry cough after several weeks. The prescriber would like to continue blocking the renin–angiotensin system but avoid this adverse effect. Which alternative agent is most appropriate?

A. Losartan B. Amlodipine C. Hydrochlorothiazide D. Metoprolol tartrate

Question 10

A pharmacist is counseling a female patient of childbearing potential who is starting isotretinoin for severe acne. Which counseling point is most critical to emphasize?

A. Avoid all dairy products while taking the medication B. Do not drive or operate machinery while taking the medication C. Use effective birth control and follow required pregnancy prevention program instructions due to high teratogenic risk D. Take the medication on an empty stomach with a full glass of water